Don’t have time to read all the other comments, so don’t mind the overlap, if any:
I’ve been using Qubes on a laptop with i7-1065G7 for well over a year now. Both R4.0 and R4.1 work perfectly fine, especially after the R4.0.4 update that upgraded the initial kernel, so installation using older software that doesn’t support the latest hardware is no longer a pain.
There isn’t a real reason to jump into R4.1, as it’s still in its alpha stage and might be less secure than R4.0, but unlikey to be more so. For example, since R4.1 dom0 uses Fedora 32, which hasn’t reached EOL, it’s constantly receiving updates, so your dom0 (the most sensitive part of the system) is constantly being fed new, possibly troublesome, code. On top of that, the QRexec overhaul means that a lot of existing documentation involving Qubes policies no longer applies.
Furthermore, there are indications that R4.1 is actually slower than R4.0 due to changes in the newer Xen (as demonstrated in my Qubes startup test thread), and this might still be true now.
This makes it hard to justify the time and emotional cost of working with an unpolished, buggy system from a purely functional point of view (maybe you just like shiny new things, testing, and contributing, which is great).
If your current hardware is old and you’re unsatisfied running R4.0 on it, then by all means go for it; if you’re satisfied but just feel RAM-constrained, get more RAM (relatively cheap nowadays). All in all, I wouldn’t go out and get a new PC just for R4.1.
Not technically trained; consume advice with salt