I’ve did some research and I am not sure how to find what I’m looking for.
I’ve installed Qubes OS 4.2. I have a templateVM in debian-12-xfce and installed the blueman, bluez and bluetooth packages on it. When I launch the Bluetooth manager from the sys-usb system qube to synchronize my Bluetooth mouse (Logitech MX Anywhere 3S), it connects and works perfectly, but when I restart my computer afterwards, I need to resynchronize the bluetooth mouse again. I don’t know what I’m missing.
I guess you need to make persistent files with the device settings. (it may be in /var/lib/bluetooth/, but I did not check it and may be I’m wrong or not complete).
Read How to make any file persistent (bind-dirs) | Qubes OS how to do that.
Also depending on your settings you may use disposable sys-usb. In that case you need to make the files persistent in the disposable template for sys-usb.
Unfortunately it’s not working, I modified the qubes.USB file in dom0 and changed deny to allow and now the mouse is recognized. When I start the laptop it asks me if I want to authorize the Bluetooth in dom0. I don’t know if it’s the proper way but it’s working on my side.