Audio issues since last update

Are you able to open PulseAudio Volume Control using pavucontrol command?
Did you change “Set as fallback” device in “Output Devices”?
You can also change the playback device in “Playback” tab.

I guess something is wrong in your dom0, it should be either pipewire or pulseaudio, not both.
Switch your audio to pipewire in dom0, it should remove pulseaudio: