AppVMs fail to start on 4.2.0 RC-3

I’m running into the same errors when I install without any VM setup and then use the graphical install, which I need to do since I have to disable a PCI device before. Installing everything directly leaves me with a system with quite some errors in the journal: Installer corrupts installation medium (+ bounty for help) - #5 by Minio

Have you used the built-in verification when installing your system? Did it fail by any chance?
In your journal, do you see any interesting red errors such as faulty PM modules on sudo?